This is what you need when you want a bit more functionality and more advanced features on your site. Content Mangement Systems, live chat, secure mailers, information listings with search capablities (such as a real estate site), and online stores are all examples of the kinds of things that can be done using PHP and MySQL (if a database is required).

WordPress itself is a PHP/MySQL application, as are most of the most popular open source and commercial applications on the market today, so that should give you an idea of its power and popularity.

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